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Unlabeled1hybrid Unlabeled1hybrid The effect is not uniform across patients. Predictors of treatment-emergent suicidality include younger age, prior non-suicidal self-injury, female gender, and depression as the treatment indication, suggesting an interaction between patient vulnerability factors and SSRI pharma…
Unlabeled1hybrid FDA analysis of 24 RCTs involving 4,582 children and adolescents found that the rate of suicidal thinking and behavior was 4% for those given an SSRI versus 2% for placebo, meaning approximately 1-3 additional patients per 100 treated developed treatment-emergent suicidality bey…
Unlabeled2hybrid SSRIs can cause treatment-emergent suicidal ideation in a small subset of patients who had no suicidal thoughts prior to treatment, most likely via an activation syndrome mechanism rather than a direct pharmacological effect on suicidal intent.
Unlabeled2hybrid The replication crisis is primarily a structural incentive problem — publication bias, p-hacking, and questionable research practices are driven by a system that rewards positive results — not a problem of individual researcher dishonesty.