Claim6214751c3b5714e9952dad159f6255a841a18524688b7559b49fad440ce1e54a·My Arguments

Evidence beyond roughly four years, and in younger or low-cardiovascular-risk populations, remains thin, and at least one meta-analysis reports an unresolved pancreatitis signal (RR ~1.44) that attenuates after adjustment — so the favorable balance is established for high-cardiovascular-risk adults over a multi-year horizon, not proven for indefinite use across all populations.

Evidence (1)

Rates of pancreatitis and pancreatic cancer among GLP-1 receptor agonists: systematic review and meta-analysis of RCTs
Reports an overall elevated pancreatitis RR (~1.44) that loses significance on stratification, and notes limited very-long-term data.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457091/

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