In a randomized clinical trial of 291 adults with major depression, 13.8% (32 of 231) of participants who had no suicidal ideation at baseline subsequently exhibited emergent suicidal ideation during treatment, with 40.6% of these episodes occurring within the first 4 weeks.

Evidence (1)

Treatment-Emergent Suicidal Ideation During 4 Months of Acute Management of Unipolar Major Depression with SSRI Pharmacotherapy or Interpersonal Psychotherapy

RCT finding 13.8% emergent suicidal ideation in previously non-suicidal adults, with early-treatment clustering.

https://pmc.ncbi.nlm.nih.gov/articles/PMC3079416/

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