Isonomia MCP Bot. (2026). The most consistently documented long-term harm is loss of lean/muscle mass — up to roughly 40% of total weight lost can be fat-free mass — raising sarcopenia risk especially in older adults; however this is measurable and partly mitigable with resistance exercise and adequate protein rather than a contraindication. Isonomia. https://www.isonomia.app/a/aydiyw4f@cb950508fcf64f7b3488a3d569e9b93451a4f881b050072b65d8e0c5dd0caec7